Octulosonic Acid, Occurred in a Ciprofloxacin Resistant Strain of Francisella
نویسندگان
چکیده
Pathology Division; Bacteriology Division; Center for Genome Sciences; Department of 12 Molecular and Translational Sciences; the United States Army of Medical Research Institute of 13 Infectious Diseases; Fort Detrick, MD 21702 14 15 Institut de Recherche Biomédicale des Armées, Département de Biologie des Agents 16 Transmissibles, Unité de Bactériologie/UMR_MD1, B.P. 73, F-91220 Brétigny-sur-Orge, 17 France 18 19 *Current address:Veterinary Pathology Services, Joint Pathology Center, Silver Spring, MD 2
منابع مشابه
A spontaneous mutation in kdsD, a biosynthesis gene for 3 Deoxy-D-manno-Octulosonic Acid, occurred in a ciprofloxacin resistant strain of Francisella tularensis and caused a high level of attenuation in murine models of tularemia
Francisella tularensis, a gram-negative facultative intracellular bacterial pathogen, is the causative agent of tularemia and able to infect many mammalian species, including humans. Because of its ability to cause a lethal infection, low infectious dose, and aerosolizable nature, F. tularensis subspecies tularensis is considered a potential biowarfare agent. Due to its in vitro efficacy, cipro...
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UNLABELLED The highly virulent Francisella tularensis subsp. tularensis has been classified as a category A bioterrorism agent. A live vaccine strain (LVS) has been developed but remains unlicensed in the United States because of an incomplete understanding of its attenuation. Lipopolysaccharide (LPS) modification is a common strategy employed by bacterial pathogens to avoid innate immunity. A ...
متن کاملConsequences of delayed ciprofloxacin and doxycycline treatment regimens against Francisella tularensis airway infection.
This study examines the efficacy, bacterial load, and humoral response of extensively delayed ciprofloxacin or doxycycline treatments following airway exposure of mice to Francisella tularensis subsp. holarctica (strain LVS) or to the highly virulent F. tularensis subsp. tularensis (strain SchuS4). A delay in onset of both antibiotic treatments allowed the rescue of all LVS-infected animals. Ho...
متن کاملStandardized broth microdilution antimicrobial susceptibility testing of Francisella tularensis subsp. holarctica strains from Europe and rare Francisella species.
OBJECTIVES Tularaemia is a widespread zoonosis in Europe caused by Francisella tularensis subsp. holarctica. Because of a lack of standardized CLSI-approved antibiotic susceptibility data from European Francisella strains, the antibiotic susceptibilities of a selection of F. tularensis subsp. holarctica isolates originating from Germany, Austria, France, Spain and other European countries were ...
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تاریخ انتشار 2016